In Vivo Pharmacology

BRF preclinical In vivo research platform has infrastructure and In-house set up for a broad range of animal models to conduct efficacy studies in various disease models in several therapeutic areas such as CNS (Central Nervous System) disorders, metabolic disorders, inflammation and pain.

All experimental procedures involving animals are approved by the Institutional Animal Ethics Committee (IAEC) under the supervision of Committee For The Purpose of Control and Supervision on Experiments on Animals (CPCSEA). Establishment and validation of various disease models are an ongoing effort being added.

Neurological Disorder Model - Depression & other CNS disorders

Metabolic Disorder - Diabetes Mellitus Animal models

Pain Models - Peripheral & Central

In vivo Skin disorders - Psoriasis & Dermatitis Animal models

Pharmacokinetics

  • Rat - oral & Parenteral
  • Mice - oral & Parenteral
  • Rabbit - oral & Parenteral

BRF provides a complete set of preclinical drug development services.

Pharmacokinetics/ Pharmacodynamics
Respiratory System (Whole Body)
Central Nervous System (Irwin Test)
Cardiovascular System (hERG)
Invitro DMPK studies
  • Premeability & P-gp assessment
  • Metabolism studies
  • Microsomal Stability
  • Hepatocytes Stability
  • Plamsa Protein Binding
  • Plasma/Whole Blood Stability
  • Blood to Plasma ratio
Bio-analytical/Bioequivalence studies
Efficacy animal Model Studies
  • Wound Healing Studies
  • Anti-Diabetic Studies
  • Cholesterolemia studies
  • Anti-Coagulant Studies
  • Pain & Inflammation Studies
  • Obesity Studies
  • epatotoxicity Studies
  • Other Customized Studies